|BritishLabradors.com does all available DNA testing of their sires and dams for genetic abnormalities to give our puppies a genetic advantage. As a result of this testing, our breeding stock being homozygous (meaning non-affected, non-carrier) or heterozygous (non-affected, carrier) for these genetic abnormalities, we guarantee that the dog you purchase from us will never be affected by these problems.
We challenge you to find another breeder doing all the genetic DNA testing we do. Breeders doing DNA testing should be able to provide you with the genetic laboratory's DNA Accession Number or DNA ID Number as proof of testing. We publish all of our DNA testing results for each of our sires and dams on the pedigree/photos pages. We use Optigen and DDC Veterinary and Paw Print Genetics laboratories for our testing.
It is important to recognize that being clear or a carrier are both clinically normal conditions. If you want a puppy and have no intention of breeding then a puppy that is either clear or a carrier will be equally acceptable.
Listed below are the DNA genetic tests we currently do on each of our breeding sire and bitches:
‘Carrier’ is the term given to an individual (of any species) that carries a single copy of a
recessive mutation that is associated with a specific inherited condition, usually an inherited
disorder. An individual will only suffer from a recessive disorder if it inherits two copies of the
causal mutation, one from each parent. If it inherits a single copy of the mutation it will remain
healthy but will pass the mutation on to about half of its offspring.
Knowing which dogs carry the mutation and
which don’t (the so-called ‘clear’ dogs) enables breeders to make sensible choices about the dogs
they mate together. All dogs can be safely bred provided at least one of the mating pair is
clear of the mutation.
Breeding to eliminate all affected and carrier dogs might at first seem attractive, but this might lead to dogs with otherwise excellent characteristics being ruled out unnecessarily and narrowing of the gene pool. If carriers are prevented from the breeding the opportunity to pass the rest of their genetic material to the next generation is also lost and the genetic diversity of the remaining population is thus reduced. A breeder who intends to breed a dog who is a carrier, must breed to a clear (non-carrier, non-affected) mate.
1. Centronuclear Labrador Myopathy (CNM,ARMD,PTPLA)
2. Progressive Retinal Atrophy (PRA-PRCD, CPRA, PRA)
3. Exercise Induced Collapse (EIC)
4. Inherited Retinal Dysplasia (RD)
5. OculoSkeletal Dysplasia (OSD, OSD1)
6. Degenerative Myelopathy (DM)
7. Hereditary Nasal Parakeratosis (HNPK)
8. Skeletal Dysplasia 2 (Dwarfism, SD2)
New genetic tests are added as they become available. Want to help the research of canine genetic abnormalities? Register your dog with The American Kennel Club who funds much of the research of canine genetic abnormalities. A portion of your registration fee goes directly toward funding canine genetic research. Also visit the AKC Canine Health Foundation and contribute and fund the research that helps dogs live longer, healthier lives!